Perricone MD High Potency Classics Face Firming Serum, 2 oz. is the best serum for wrinkles. This serum reduces the appearance of wrinkles, in length, width, and depth. Use this on dry, normal, oily, or combination skin. Skin looks firmer, gets hydration from hyaluronic acid, and benefits from antioxidants in the serum. This highly potent serum makes skin look smoother and also reduces pore size.